British Journal eBook

eBook Journal in PDF, ePub, Mobi and Kindle Formats

Investigating and harnessing T-cell functions with engineered immune receptors and their ligands

Investigating and harnessing T-cell functions with engineered immune receptors and their ligands

T-cells are an essential component of the immune system that provide protection against pathogen infections and cancer and are involved in the aetiology of numerous autoimmune and autoinflammatory pathologies. Their importance in disease, the relative ease to isolate, expand and manipulate them ex vivo have put T-cells at the forefront of basic and translational research in immunology. Decades of study have shed some light on the unique way T-cells integrate extrinsic environmental cues influencing an activation program triggered by interactions between peptide-MHC complexes and the antigen-recognition machinery constituted of clonally distributed T-cell receptors and their co-receptor CD4 or CD8. The manipulation of these molecular determinants in cellular systems or as recombinant proteins has considerably enhanced our ability to understand antigen-specific T-cell activation, to monitor ongoing T-cell responses and to exploit T-cells for therapy. Even though these principles have given numerous insights in the biology of CD8+ T-cells that translate into promising therapeutic prospects, as illustrated by recent breakthroughs in cancer therapy, they have proven more challenging to apply to CD4+ T-cells. This Research Topic aims to provide a comprehensive view of the recent insights provided by the use of engineered antigen receptors and their ligands on T-cell activation and how they have been or could be harnessed to design efficient immunotherapies.

Download Now

Author
Publisher Frontiers Media SA
Release Date
ISBN 2889194132
Pages 192 pages
Rating 4/5 (31 users)

Table 1 | Potential immune checkpoint receptor targets for genome editing in the context of cancer adoptive cellular ... (66), Meyaard (67) SHP-2 Receptors for soluble regulatory mediators PGE2 receptors EP2/4 Inhibition of T-cell ...

More Books:

Investigating and harnessing T-cell functions with engineered immune receptors and their ligands
Language: en
Pages: 192
Authors: Bruno Laugel
Categories: Immunologic diseases. Allergy
Type: BOOK - Published: 2015-01-22 - Publisher: Frontiers Media SA

GET EBOOK

T-cells are an essential component of the immune system that provide protection against pathogen infections and cancer and are involved in the aetiology of nume
Multichain Immune Recognition Receptor Signaling
Language: en
Pages: 357
Authors: Alexander Sigalov
Categories: Medical
Type: BOOK - Published: 2008-12-16 - Publisher: Springer Science & Business Media

GET EBOOK

This book shows how the structural similarity of MIRRs determines the general principles underlying MIRR-mediated transmembrane signaling mechanisms. In so doin
Rheumatology E-Book
Language: en
Pages: 2123
Authors: Marc C. Hochberg
Categories: Medical
Type: BOOK - Published: 2022-07-29 - Publisher: Elsevier Health Sciences

GET EBOOK

Covering both the scientific basis of rheumatology and practical, clinical information for rheumatologists and trainees, Rheumatology, 8th Edition, remains a le
Immune Receptors
Language: en
Pages: 301
Authors: Jonathan P. Rast
Categories: Medical
Type: BOOK - Published: 2011-06-29 - Publisher: Humana Press

GET EBOOK

Immunology has made significant progress in the past decade, driven forward by rapidly advancing technology and a renewed interest in the vast realm of innate i
Cellular and Molecular Immunology E-Book
Language: en
Pages: 603
Authors: Abul K. Abbas
Categories: Medical
Type: BOOK - Published: 2021-02-19 - Publisher: Elsevier Health Sciences

GET EBOOK

Well-written, readable, and superbly illustrated, Cellular and Molecular Immunology, 10th Edition, continues the tradition of excellence established through mul
Immunology
Language: en
Pages: 350
Authors:
Categories: Medical
Type: BOOK - Published: 2008 - Publisher: Lippincott Williams & Wilkins

GET EBOOK

"Concise review of immunology to be used by resident medical students"--Provided by publisher.
Cellular and Molecular Immunology E-Book
Language: en
Pages: 600
Authors: Abul K. Abbas
Categories: Medical
Type: BOOK - Published: 2017-03-10 - Publisher: Elsevier Health Sciences

GET EBOOK

The top required and recommended immunology text worldwide, Cellular and Molecular Immunology by Drs. Abul K. Abbas, Andrew H. H. Lichtman, and Shiv Pillai, is
Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation
Language: en
Pages: 430
Authors: Gerard Socie
Categories: Science
Type: BOOK - Published: 2018-11-22 - Publisher: Academic Press

GET EBOOK

Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and Translation, Second Edition once again provides clinical and scien
Immunity
Language: en
Pages: 426
Authors: Anthony DeFranco
Categories: Science
Type: BOOK - Published: 2007-04-05 - Publisher: New Science Press

GET EBOOK

Immunity: The Immune Response to Infectious and Inflammatory Disease presents an engaging insight into one of the most intricate yet conceptually challenging bi
Plant Immunity against Viruses
Language: en
Pages: 165
Authors: Yule Liu
Categories: Electronic book
Type: BOOK - Published: 2017-09-28 - Publisher: Frontiers Media SA

GET EBOOK

Plant viruses impose a serious threat on agriculture, which motivates extensive breeding efforts for viral resistant crops and inspires lasting interests on bas

Powered By WordPress | LMS Academic